Sunday April 18th, 2010

 

10:00 am- 4:00 pm Registration (registration desk outside Marriott meeting room on second floor; stairway to the right, just inside main entrance)

 

11:45 pm Welcome and Announcements

 

12:00 - 1:00 pm Session #1 Molecular mechanisms of spinal cord sensitization and disinhibition

 

Fernando Cervero (McGill Univ., Montreal, Quebec, Canada) Session Chair

“Molecular markers in the spinal cord of estrogen-dependent hyperalgesia”

 

Hanns-Ulrich Zeilhoffer (University of Zurich, Switzerland)

         “Subtype-selective GABA-A receptor ligands as novel analgesics”

 

Jose Antonio Lopez-Garcia (University of Alcala, Madrid, Spain)

         “Inhibitory and excitatory spinal effects of amines: changes following

         sensitization”

 

Robert W. Gereau (Washington Univ. Pain Center, St Louis, USA)

         “mGluR-dependent plasticity in the dorsal horn and its role in central

         sensitization”

 

1:00 - 2:15 pm Session #2 Glial Signaling Mechanisms in Persistent Pain

 

Ru-Rong Ji (Brigham & Women’s Hospital, Harvard, Boston, MA, USA) Session Chair

Michael Salter (Univ. of Toronto, Toronto, Canada)

         “Microglial signaling mechanisms: ATP receptors and BDNF”

Kazuhide Inoue (Kyushu University, Japan)

         “Microglial signaling mechanisms: Interferon g and receptor”

Marzia Malcangio (Kings College London, London, UK)

            “Microglial signaling mechanisms: cathepsin S and fractalkine”

Isabelle Decosterd (Univ. of Lausanne, Switzerland)

         “Astroglial signaling mechanisms: glutamate and GABA transporter”

Ru-Rong Ji (Brigham & Women’s Hospital, Harvard, Boston, MA, USA)

         “Astroglial signaling mechanisms: MAPKs and chemokines”

 

2:15 - 2:45 pm   Coffee Break

 

 2:45 - 4:15 pm Session #3 Novel Mechanisms of Gene Expression Control

 

Ted Price (University of Arizona, Tucson, Arizona, USA) Session Chair

         “Signaling to translation control machinery in DRG neurons”

 

Sandrine Geranton

         “Rapamycin sensitive gene expression modulates persistent pain states”

 

Camilla Svenson

         “mTOR-mediated regulation of  spinal sensitization in inflammatory pain”


 

Michael R. Vasko (Indiana Univ. School of Medicine, Indianapolis, IN, USA)

    "DNA Repair reduces sensory neuropathy induced by cancer therapies"

 

Carolyn Fairbanks (University of Minnesota, Minneapolis, MN USA)

          "Differential targeting of sensory neurons by AAV serotypes"

 

Luc Jasmin (UCSF, San Francisco, CA, USA)

         "The GABA-Glutamate cycle: rewriting the script with a strong hand"

 

4:15 – 5:45 pm Session #4 GPCRs and Pain I

 

Lindsay Hough (Albany Medical College, Albany NY, USA) Session Chair

         "Opioid-induced activation of brain analgesic circuits through cytochrome P450/epoxygenase

          Signaling"

Zhizhong Pan (MD Anderson, Houston, TX, USA)

         “Signaling mechanisms for DOR trafficking and function”

George Wilcox (University of Minnesota, Minneapolis MN, USA)

         “Role of PKC in analgesic synergy”

Daniela Salvemini (Saint Louis University, St. Louis MO, USA)

         “Ceramide in opiate hyperalgesia and tolerance”

Catherine Cahill (Queen's University, Kingston, Canada)

             "Ultralow dose naloxone inhibits morphine tolerance: dissociation between functional

              outcomes and glial activation"

Christopher Evans (University of California Los Angeles, CA, USA)

             "Constitutively active Mu-opioid receptors: potential therapeutic targets for analgesia

               without addiction"

 

 

5:45 – 6:15 pm – Special Session #5 – Revisiting Specificity in the Generation and Control of Pain

 

Allan Basbaum (UCSF, San Francisco, CA, USA)

 

 

7:00 pm       Welcome Reception at the Marriott  

 

 

Monday April 19th, 2010

 

8:00- 9:30 am Session #6 Forebrain Mechanisms of Pain

 

Volker Neugebauer (Univ. of Texas Medical Branch, Galveston, TX, USA) Session Chair

       “Mechanisms of amygdalo-cortical plasticity in pain”

 

Vasco Galhardo (Univ. of Porto, Porto, Portugal)

         “Desynchronization of thalamocortical information flow after peripheral nerve

           injury”

 

Min Zhuo (Univ of Toronto, Toronto, CA)

          "Erasing neuropathic pain hypersensitivity by inhibiting PKMzeta in anterior cingulate cortex"

Sabatino Maione (Univ. of Naples, Naples, Italy)

         “FAAH inhibitors or TRPV1 receptor antagonists modulate endocannabinoid levels and

          microglial caspase activation in the prefrontal cortex of  neuropathic mice”

 

Vania Apkarian (Northwestern University, Chicago, IL, USA)

         “Specificity and plasticity of the human brain in chronic pain”

 

Sean Mackey (Stanford School of Medicine, Palo Alto, CA, USA)

         “Prefrontal cortical systems in low back pain versus generalized anxiety

          disorders”

       

 

9:30 – 10:30 AM Session #7 Stress and Pain

 

Mary Heinricher (Oregon Health & Science Univ., Portland, OR, USA) Session Chair

         “Stress and recruitment of descending pain-modulating neurons”

 

Guy Simmonet (University Bordeaux, Bordeaux Cedex, France)

         “Paradoxical latent pain hypersensitivity as a pathological outcome of stress-

          induced analgesia in rats"

 

Cyril Rivat (CRICM UPMC INSERM UMRS, Paris, France)

"Chronic stress-induced spinal inflammation: effects on nociceptive threshold  and pain-related behavior"

 

Milena DeFelice (University of Arizona, Tucson, AZ, USA)

         “Triptan-induced sensitization mechanisms and headache pain”

 

10:30 – 11:00 AM – Coffee Break

 

11:00- 11:45 am Session #8 Neural Control of Peripheral Inflammation

 

David J Clark (Stanford School of Medicine, Palo Alto, CA, USA) Session Chair

         "Activation of the innate system of immunity in CRPS"


 

Wade Kingery (Stanford School of Medicine, Palo Alto, CA, USA)

         "The role of neuropeptide, cytokine, and growth factor
> signaling in CRPS"

 

Stephanos  Kyrkanides, (SUNY-Stony Brook, Long-Island, NY, USA)

         "Neurogenic inflammation in osteoarthritis”

 

11:45 – 12:45 pm Session #9 Understanding, Detecting, and Treating Osteoarthritis Pain

 

Gloria Matthews (Genzyme Orthopaedic Research, Cambridge, MA, USA) Session Chair

         “Introduction to the osteoarthritis pain landscape: Where do we stand?”

 

Bruce Kidd (Queen Mary School of Medicine, London, UK)

         “Current understanding of the biological basis for osteoarthritis pain”

 

Anna Vardanyan (Genzyme Orthopaedic Research, Cambridge, MA, USA)

         “Preclinical evaluation of osteoarthritis pain”

 

David Hunter (New England Baptist Medical Center, Boston, MA, USA)

         “Imaging osteoarthritis pain correlates”

 

12:45 -1:15 pm Special Session #10 Transgenic Insights into Modality Specific Wiring in the Periphery

 

John Wood (University College London, London, UK)

 

 

 

Tuesday April 20th, 2010

 

8:00-8:45 am Session #11 Protein-Protein Interactions in Pain

 

Michael Salter (Univ. of Toronto, Toronto, Canada) Session Chair

  “Targeting NMDA receptor interacting proteins in pain”


 

Yves de Koninck (Univ. Laval, Quebec City, Quebec, Canada)

   “Novel optical approach to reveal protein interactions in pain pathways

    in situ”

 

Yutian Wang University of British Columbia, Vancouver, BC)

         “Role of LTD in morphine addiction and tolerance”

8:45-9:30 am Session #12 Preclinical Mechanisms of Spontaneous Pain

 

Tim Brennan (University of Iowa, Iowa City, IA, USA) Session Chair

“Unprovoked guarding pain and spontaneous activity of nociceptors requires deep tissue injury”

 

 Thomas J. Martin (Wake Forest University, Winston-Salem, NC, USA)

“Intrathecal self-administration of analgesics in nerve-injured rats, spinal and supraspinal involvement"

 

Frank Porreca (University of Arizona, Tucson, AZ, USA)

         “Preclinical evaluation of spontaneous pain”

 

9:30 – 10:00 am Coffee Break

 

 

10:00-10:45 am Session #13 Biologics in Pain

 

Iain Chessell (MedImmune, Cambridge, UK) Session Chair

Jane Hughes(MedImmune, Cambridge, UK) 

         "Soluble mediators as analgesic targets for biologic approaches"

 

Anthony Rossomando (Alnylam, Boston, MA, USA)

         "Using Biologics to Prevent Neuropathic Pain"

 

Richard Torres (Regeneron, Tarrytown, NY, USA)

         "Using Velocigene and Velocimmune to understand and
treat pain"

 

 

10:45 - 11:30 am Session #14 GPCRs and Pain II

 

Lucia Negri (Sapienza University of Rome, Rome, Italy) Session Chair 

         “Bv8/Prokineticin sensitization in inflammation and pain”

 

Brad Taylor (University of Kentucky, Lexington, KY, USA)

         “Long-term control of hyperalgesia by spinal NPY”

Chris Fowler (Umea University, Umea, Sweden)

         “Targeting peripheral endocannabinoid metabolism for the treatment of pain”

11:30 – 12:30 pm Session #15 DRG hyperexcitability and central pain mechanisms

Sue Carlton (University of Texas Medical School, Galveston, TX, USA) Session Chair

“Neuropathic pain fueled by nociceptor hypersensitivity in far and away places” 

Edgar T. Walters (University of Texas Medical School at Houston, TX, USA)

"Spontaneous activity generated in nociceptor somata may contribute to chronic pain following spinal cord injury"

Nigel Bunnett (University of California, San Francisco, San Francisco, CA, USA)

“Contribution of proteases to inflammatory pain: protease detection and imaging using activity-based probes”

Claire Hulsebosch (University of Texas Medical School, Galveston, TX, USA)

“Gliopathy contributes to persistent inflammation and dysfunction after CNS trauma”

 

 

 

 

6:00 - 7:00 pm Session #16 Cancer and Chemotherapy-induced Pain

 

Todd W Vanderah (University of Arizona, Tucson, AZ, USA) Session Chair      

        “CB₂ agonists in a model of breast cancer-induced bone pain”

 

Michela Kress (Medical University Innsbruck, Innsbruck, Austria)

         "Proinflammatory cytokines mediating hypersensitivity in a murine cancer pain

          model"

 

Sarah Flatters (King's College London, London, UK)

         "Potential causal mechanisms for chemotherapy-induced pain"

 

Jose Miguel Vela (Esteve, Barcelona, Spain)

“Sigma receptors and cancer chemotherapy induced neuropathic pain”

7:00-8:00 pm Data Blitz

Jill Recla (Jackson Labs)

“Identify novel genes and alleles associated with chronic pain susceptibility in humans using genetic mapping reference populations of laboratory mice“

Tally M. Largent-Milnes (University of Arizona, Tucson AZ, USA)

         “Bifunctional opioid agonist/NK1 antagonist for pain without rewarding behavior”

Junichi Yagi (Kyorin University School of Medicine, Tokyo, Japan)

“Membrane depolarization is required for muscimol-induced blockade of action potential propagation in rat DRG neurons”

Matt Rowan (The University of Texas, San Antonio TX, USA)

         "Local estrogen rapidly enhances BK- induced thermal allodynia"

Vinicio Granados-Soto (Cinvestav, Sede Sur, México, D.F., Mexico)

            “Role of the Na+/H+ exchanger 1 and 5 in inflammatory pain”

Indranil Mukhopadhyay (Glenmark Research Cntr, Navi Mumbai, Maharashtra, India)

         “Novel, potent, selective and orally efficacious TRPA1 antagonist for clinical development in

         potential treatment of neuropathic pain”

R. Ben Messinger (Univeristy of Virginia, Charlottesville, VA, USA)

           "Modulation of Cav3.2 T-type calcium channels in sensory neurons alleviates painful

           streptozocin-induced diabetic neuropathy in adult rats"

Fiona Russell (University of Calgary, Calgary, Canada)

          "Proteinase activated receptor-4 has a pro-nociceptive effect in rat knee joints which is mast

           cell dependent"

Niklas Schuelert (University of Calgary, Calgary, Canada)

          "Modulation of the body's natural cannabinoid system reduces

           nociception in rodent models of osteoarthritis"

Rick Lennertz (Med College Wisconsin, Milwaukee, WI, USA)

          "Sanshool-induced tingling paresthesia"

 

Wednesday April 21st, 2010

 

8:00-9:00 am Session #17 Potassium channels

 

Diana Bautista (University of California, Berkeley, Berkeley, CA, USA) Session Chair

         “Mechanisms of sanshool-evoked tingling paresthesia”

Dan Minor (UCSF, San Francisco, CA, USA)

         “Structural insight into TREK-1 gating by thermal and mechanical stimuli”

Constantine Sarantopolous (Medical College of Wisconsin, Milwaukee, WI USA)

         “ATP-sensitive potassium channel activity following nerve injury”

Sandy Chaplan (Johnson & Johnson, La Jolla, CA, USA)

         “HCN channels as drug targets for treating pain”

 

9:00- 10:00 am Session #18 Mechanisms of Itch

 

Glenn Giesler (University of Minnesota, Minneapolis, MN, USA) Session Chair

 

Earl Carstens (University of California, Davis, Davis, CA, USA)

         “Itch sensitization in a mouse model”

 

Steve Davidson (Washington University School of Medicine, St. Louis, MO, USA)

         “Spinal mechanisms of itch”

 

Bob LaMotte (Yale University School of Medicine, New Haven, CT, USA)

         “Mouse models of human itch”

 

Martin Schmelz (University of Heidelberg, Mannheim, Germany)

         “Similar mechanisms of sensitization for pain and itch?”

 

10:00 -10:30 am Coffee Break

 

10:30-11:30 pm Session #19 Calcium channels

 

Terry Snutch (NeuroMed Pharmaceuticals, Vancouver, Canada) Session Chair

        

Gerald Zamponi (University of Calgary, Calgary, Canada)

“Regulation of T-type calcium channels by CCR2 receptor ligands - a dual approach to treating pain?”

Emmanuel Bourinet (Institut de Génomique Fonctionnelle, Montpellier, France)

          “Direct functional coupling between the Cav3.2 T-type calcium channel and nitric oxide
           synthase contributes to nociception"

Slobodan Todorovic  (University of Virginia Health System, Charlottesville, USA)

“Free radical signaling underlies selective effects of nitrous oxide (laughing gas) on T-type calcium channels in the pain pathway”

 

Michael Hildebrand (NeuroMed Pharmaceuticals, Vancouver, Canada)

“Novel small organic compounds that alter sodium and calcium channel biophysical properties and reduce excitability of peripheral nociceptors and dorsal horn spinal cord neurons”

 

11:30 - 12:45 pm Session #20 Mechanisms of Gabapentinoids in Pain

Annette Dolphin (University College London, London, UK) Session Chair

Charlie Taylor (CPTaylor Consulting, Chelsea MI, USA)

         “Pregabalin - overview of published clinical trials and relevant pharmacology mechanisms"

Annette Dolphin (University College London, London, UK)

"The calcium channel alpha2delta subunit and its role as a 
therapeutic target in

 neuropathic pain"

David Lou (University of California, Irvine, CA, USA)

         “Mechanism of a2d1 induced behavioral hypersensitivity”

Ken-ichiro Hayashida (Wake Forest University, Winston Salem, NC, USA)

         “Does gabapentin recruit descending inhibition?”

Howard Gutstein (MD Anderson Cancer Center, Houston TX, USA)

            "Can you teach an old drug new tricks??"

 

 Trip to Stingray City

 

 

 

 

Thursday April 22nd, 2010

   

8:00 - 9:30 am Session #21 CGRP and Pain

 

Richard Hargreaves (Merck Research Laboratories, West Point, PA, USA) Session Chair

John Macor, (Bristol Myers Squibb, Wallingford, CT, USA)

         “CGRP Antagonists, Novel Medicinal Chemistry”

Stefanie Kane (Merck Research Laboratories, West Point, PA, USA)

         “CGRP antagonists and migraine”

Henri Doods  (Boehringher Ingelheim, Bieberach, Germany)

         “CGRP antagonists and pain”

Karl Messlinger  (University of Ehrlangen-Nurnberg, Germany)

         “Trigeminal CGRP studies”

Volker Neugebauer (Univ. of Texas Medical Branch, Galveston, TX, USA)

         “CGRP in spinal cord and amygdala”

Richard Hargreaves (Merck Research Laboratories, West Point, PA, USA)

         "PET Imaging CGRP receptors in the brain"

 

 

9:30–10:30 am Session #22 A Multipartitie Synapse in Understanding Pain Mechanisms

 

Joyce DeLeo: (Dartmouth Medical School, Hanover, HN, USA) Session Chair

           Introduction

 

Michael Costigan (Harvard Medical School, Boston, MA, USA)

         “Potential role of lymphocytes in chronic pain”

 

Edgar Alfonso Romero-Sandoval (Dartmouth Medical School, Hanover HN, USA)

         “Perivascular cells and CB receptors”

 

Patrick Dougherty (Univ of Texas MD Anderson Cancer Cntr, Houston, TX, USA)

         "In Vivo studies of Physiological Responses of Spinal Astrocytes"

 

Fletcher White (Loyola University, Stritch School of Medicine, Chicago, IL, USA)

"Injury-induced CCL2/CCR2 Signaling; Just Another Pro-nociceptive Factor in the Sea of Chronic Pain Disorders?"

 

 

10:30 – 11:00 AM – Coffee Break

 

11:00 – 12:15 Session #23 Sex and Pain

 

Richard Traub (University of Maryland Dental School, Baltimore, MD, USA) Session Chair

 

Dean Dessem (University of Maryland Dental School, Baltimore, MD, USA) 

         “Sex differences in movement-induced muscle pain”

 

Jin Ro (University of Maryland Dental School, Baltimore, MD, USA)

         “Sex differences in peripheral opioid receptor mechanisms”

 

Joel Greenspan (University of Maryland Dental School, Baltimore, MD, USA)

“Hormonal tides and pain:  menstrual cycle effects upon brain responses to pain”

 

Rich Traub (University of Maryland Dental School, Baltimore, MD, USA)

         “Hormonal modulation of visceral pain”

Jill Fehrenbacher (University of Texas HSC, San Antonio, TX, USA)

        "Effects of estrogens on human nociceptors"

 

 

12:15 – 12:45 pm Special Session #24 RNAi and Applications to Pain: From Target Validation to Therapeutics

Dinah Sah (Alnylam Pharmaceuticals, Inc. Cambridge, MA, USA)

 

 

 

 

Friday April 23rd, 2010

   

8:00 - 9:00 am Session #25 Basic Science of Migraine

 

Greg Dussor (University of Arizona, Tucson, AZ, USA) Session Chair

Michael Ossipov (University of Arizona, Tucson, AZ, USA)

         "CSD and headache pain"

Ian Meng (University of New England, Biddeford, ME, USA)

         "Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls 
         (DNIC) in dura sensitive medullary dorsal horn neurons"

 

Greg Dussor (University of Arizona, Tucson, AZ, USA)

         “Activation of Dural Afferents by Small Changes in Extracellular pH”

 

Michael Gold (Univ. of Pittsburgh, Pittsburgh, PA, USA)

         “Mechanisms of Dural Afferent Excitability”

 

9:00 – 9:45 am Session #26 Clinical Migraine

 

David Dodick (Mayo Clinic, Scottsdale AZ, USA) Session Chair

         “Migraine and other primary headache disorders”

 

Peter Goadsby (University of San Francisco, San Francisco CA, USA)

         “Mechanisms of migraine pain”

 

John Andrews (NeurAxon, Toronto, Canada)

         “nNOS inhibition as a treatment strategy for headache pain”

 

9:45 AM – 10:15 AM – Coffee Break

 

10:15 – 11:15 am Session #27 Conversion of Acute to Chronic Pain

 

Dave Yeomans (Stanford University, Stanford, CA, USA) Session Chair

         “Pain Chronicity and Oxytocin Receptors in Primary Afferents"

 

Julien Mamet (Laboratoire de Pharmacol Medicale, Clermont-Ferrand, France)

         "From acute to chronic pain: a genome-wide leap"

 

David Borsook (McLean Hospital, Belmont, MA, USA)

 

Uhtaek Oh (Seoul National University, Seoul, Korea)

         "Role of ANO1, a cloned Ca2+-activated Cl- channel in nociception"

 

11:15-12:15 pm Session #28  Opioid-induced Hyperalgesia: Mechanisms and Clinical Relevance

 

Jurgen Sandkuhler (Center for Brain Research, Medical Univ of Vienna, 
Austria) Session Chair

         “Synaptic mechanisms of OIH”


 

Martin Angst (Stanford School of Medicine, Palo Alto, CA, USA)

“Surrogate markers of OIH in humans: Are they valid and where do we stand?”




Michael Rowbotham (UCSF-Mount 
Zion Pain Management Center, San Francisco, CA, USA)

         "Clinical evidence of opioid hyperalgesia - yes or no?"

Michael Morgan (Washington State University Vancouver, WA, USA)

         "Contribution of mu-opioid receptor internalization to morphine antinociception and

           tolerance in the rat"

 

12:15 - 1:30 pm Session #29 TRP channels and pain

 

Cheryl Stucky (Med College Wisconsin, Milwaukee, WI, USA) Session Chair

         "TRPA1: a potential target for 
mechanical sensitivity"

Stuart Bevan (King's College London, UK)

         “Novel endogenous modulators of TRPA1”

Pierangelo Geppetti (University of Florence, Florence, Italy)

         “TRPA1: from pain to inflammation”

Mark Zylka (University of North Carolina, Chapel Hill, NC, USA)

         “Regulation of thermal and mechanical nociception by ectonucleotidases"

Samer R. Eid (Merck Research Laboratories, West Point, PA, USA)

            "TRPV1 Antagonists: Are They Too Hot to Handle?"

 

 

 

END OF SESSIONS

 

Friday Evening - Farewell Beach Barbecue at the Marriott