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Spring Pain Research Conference
10th Year Anniversary
April 26th – May 3rd, 2008 Grand Cayman, BWI
Sunday April 27th, 2008
10:00 am-4:00pm Registration (registration desk outside Marriott meeting room
on second floor; stairway to the right, just inside main entrance)
12:00 pm Welcome and Announcements
12:15-1:15 pm Session #1 Voltage-gated Ion Channels (Calcium) Terry Snutch (NeuroMed Inc., Vancouver, Canada) Co-Chair Gerald Zamponi (University of Calgary, Calgary, Canada) Co-Chair "The role of alternate splicing of N-type channels in pain"
Richard Lewis (University of Queensland, Brisbane, Australia) "Painless toxins: contrasting effects of direct and indirect inhibitors of calcium channels"
Slobodan Todorovic (University of Virginia, Charlottesville VA, USA) "Molecular mechanisms of redox modulation of T-type calcium channels in peripheral nociceptors"
Steve Arneric (NeuroMed Pharmaceuticals, Vancouver, Canada) "T-type channels as pharmacological targets for treating pain"
1:15-2:30 pm Session #2 CB2 Mechanisms: Selective Agonists and Pain
Praveen Anand (Imperial College London, London UK) Chair "CB2 localisation and agonist-mediated inhibition in human sensory neurons"
Garth Whiteside (Wyeth Research, Princeton NJ, USA) "Central and peripheral sites of action of CB2-selective agonist compounds" Smriti Iyengar (Lilly Research Laboratories, Indianapolis, IN, USA) “Inhibitors of Endocannabinoid Inactivation”
Chris Fowler (Umea University, Umea, Sweden)
“Endocannabinoids and pain - the cyclooxygenase connection”
Andrea Hohmann (University of Georgia, Athens GA, USA) “Cannabinoid CB2 Mechanisms of Pain Suppression”
2:30-3:00 pm Coffee Break
3:00-4:00 pm Session #3 MAP Kinases and Pain
Ru-Rong Ji (Brigham & Women’s Hospital, Harvard, Boston, MA, USA) co-Chair “JNK regulation of persistent mechanical allodynia”
Gary Strichartz (Brigham & Women’s Hospital, Harvard, Boston, MA, USA) co-Chair “MAP kinase regulation of postoperative pain”
Yarimar Carrasquillo (Washington Univ., St. Louis, MO, USA)
“Activation of ERK in the amygdala and pain perception”
Marzia Malcangio (Kings College London, Strand, London, UK)
“Sensory fiber transmission and the activation of ERK in the spinal cord”
4:00-4:45 pm Session #4 Cytokines and Pain
Richard Torres (Regeneron Pharma Inc., Tarrytown, NY, USA) Chair
Prisca Honore (Abbott Laboratories, Abbott Park, Il, USA)
"Cytokine modulation of neuropathic pain"
Ke Ren (University of Maryland, College Park, MD, USA)
“IL-1 beta-induced hyperalgesia in rats”
Richard Torres (Regeneron Pharma Inc., Tarrytown, NY, USA)
“IL-1 blockade reduces pain and inflammation in animal models of gout”
4:45-5:15 pm Session #5 Clinical Trial Results of TRPV1 Compounds
Narendar Gavva (Amgen Inc., Thousand Oaks, CA, USA) Chair
"AMG 517, a selective TRPV1 antagonist causes marked hyperthermia in humans"
Gil Wong (Anesiva, Inc., South San Francisco, CA, USA)
“Clinical research with TRPV1 agonist for analgesia”
6:00 pm Welcome Reception at the Marriott
Monday April 28th, 2008
8:00-9:30 am Session #6 Sodium Channels and Pain
Sulayman D. Dib-Hajj (Yale Univ. School of Medicine, New Haven, CT, USA) Chair
“Sodium channels and painful neuropathies”
Theodore R. Cummins (Indiana Univ. School of Medicine, Indianapolis, IN, USA)
“Molecular Pharmacology of Nav1.7 channels”
Michael F. Jarvis (Abbott Laboratories, Abbott Park, Illinois, USA)
“Role of Nav1.8 sodium channels in chronic pain states”
Alexander M. Binshtok (Harvard Medical School, Boston, MA, USA)
“Pain-specific anesthesia”
Katharina Zimmermann (Harvard Medical School, Boston, MA, USA)
"Nav1.8 - a sodium channel for pain in the cold"
Tarek Samad (Harvard Medical School, Boston, MA, USA)
"Cytokines as regulators of nociceptor excitability and sodium channel activity”
9:30- 10:30 am Session #7 New Advances in Musculoskeletal Pain
Pat Mantyh (Univ. of Arizona, Tucson, AZ, USA) Chair
Susan E. Bove (Pfizer Global Res. & Devel., Groton, CT, USA)
“Preclinical modeling of osteoarthritis pain: challenges and opportunities”
Julia Inglis (Imperial College London, London, UK)
“Pain in Osteoarthritis. Mechanisms and Therapies”
Sarah JL Flatters (King's College London, UK)
“Skin/muscle incision and retraction (SMIR) as a model for persistent postoperative pain”
Pat Mantyh (Univ. of Arizona, Tucson, AZ, USA)
”Skeletal pain: causes, consequences, and therapeutic opportunities”
10:30-10:45 am Coffee Break
10:45- 11:30 am Session #8 Endothelins and their Role in Cancer Pain
Guy Hans (Antwerp Univ. Hospital, Belgium) Chair
“Neurosensory effects of prolonged administration of endothelin-1”
Gary Strichartz (Harvard Medical School, Boston, MA, USA)
“Nociceptive Sensitization by ET-1: Local and Segmental Effects Incorporate Similar Mechanisms”
Brian Schmidt (Univ. of California San Francisco, CA, USA)
"The role of ET-1 in carcinoma-induced mechanical hypersensitivity"
11:30- 1:00 pm Session #9 Peripheral Mechanisms of Pain and Analgesia
Robert Spencer (Cara Therapeutics Inc. Shelton, CT, USA) Chair
“Pharmacological profile of novel peripheral kappa opioid agonists “
Christoph Stein (Freie Universität Berlin, Berlin, Germany)
“Therapeutic issues: Efficacy, tolerance, disease modifying effects”
David Clark (Stanford University Medical Center, Palo Alto, CA, USA)
“Opioid Control of Cytokine Expression after Incision: Acute and Chronic Dosing”
Uhtaek Oh (Seoul National University, Seoul, Korea)
“Histamine causes itch via activation of TRPV1”
Todd W. Vanderah (Univ. of Arizona, Tucson, AZ, USA)
"NGF-Dependent Mechanisms of Opioid- Induced Hyperalgesia"
Michael R. Vasko (Indiana Univ. School of Medicine, Indianapolis, IN, USA)
"NGF-Induces Peripheral Sensitization by Multiple Mechanisms" 6:00-8:00 pm Data Blitz
Ed Kaftan (Wyeth Research laboratories, NJ, USA)
"SNRI compounds as blockers of voltage-gated ion channels"
Junichi Yagi (Kyorin Univ. School of Medicine, Tokyo, Japan)
“In vivo patch clamp recordings of rat DRG neurons”
Samer R. Eid (Merck Research Laboratories, PA, USA)
"Pharmacological blockade of TRPA1 attenuates mechanical hypersensitivity in models of inflammatory and neuropathic pain." Tony Rossomando (Biogenidec, Boston, MA, USA) "Effects of Artemin in Neuropathic Pain: Potenial for disease modification?" Jeff Kennedy (Wyeth Research laboratories, NJ, USA)
"Effect of inflammation on permeability of the blood-brain barrier"
Laura Stone (McGill University, Montreal, Quebec, Canada)
“Developing an animal model of low back pain”
Milena De Felice (University of Arizona, Tucson, AZ, USA)
“Suppression of cutaneous allodynia resulting from dural inflammation by sumatriptan and a selective nNOS inhibitor”
Lucy Vulchanova Hart (Univeristy of Minnesota, Minneapolis, MN, USA)
“The Neurosecretory Protein VGF mediates p38 MAPK-dependent thermal hyperalgesia” Juan Miguel Jimenez- Andrade (University of Arizona, Tucson, AZ, USA) "A new model to assess fracture pain and skeletal healing"
Christophe Altier (Univ. of Calgary, Alberta, Canada)
"Regulation of T-type calcium channels by Rho-associated kinase : contribution to pain sensitization ?"
Cathy Cahill (Queen's Univ. Kingston, ON)
"Glial metabolic inhibitors modulate GPCR trafficking in neuropathic pain"
Luis R. Gardell (Cara Therapeutics, Inc. Shelton, CT, USA)
”Pharmacological profile of a novel series of CB2 selective agonists with efficacy in visceral, inflammatory and neuropathic pain" Anthony Bannon (Icagen Inc. Durham, NC, USA)
"Small molecule KCNQ openers for the potential treatment of pain" Tuesday April 29th, 2008
8:00-9:00 am Session #10 Rapid Pain Modulation with Nuclear Receptor Ligands
Bradley Taylor (Tulane Univ., New Orleans, LA, USA) Chair
“Rapid inhibition of neuropathic pain through spinal PPAR-gamma receptors”
Jesse LoVerme (Univ. California Irvine, Irvine, CA, USA)
"Rapid analgesia through peripheral PPAR-alpha receptors"
Jill Fehrenbacher (Univ. of Texas HSC, San Antonio, TX, USA)
“The role of the GPR30 in inflammatory pain”
William Clarke (Univ. of Texas HSC, San Antonio, TX, USA)
“Rapid actions of estrogen to regulate inflammatory mediator signaling in trigeminal ganglion cultures”
9:00- 10:15 am Session #11 Chemokines and Pain
Catherine Abbadie (Merck Research Labs, NJ, USA) Chair
“Effects of CCR2 antagonists in pre-clinical pain models”
Sonia Bhangoo (Northwestern Univ., Chicago, IL, USA)
“Chemokines; the second wave of nociceptive neuromodulators?”
Stéphane Mélik Parsadaniantz (Hospital Saint Antoine, Paris, France)
“Implication of the chemokine MCP-1/CCL2 in spinal nociceptive neurotransmission”
Yves De Koninck (Univ. Laval, Quebec City, Quebec, Canada)
“Role of MCP-1-CCR2 signaling in triggering spinal neuroimmune reaction to peripheral nerve injury”
Marzia Malcangio (Kings College London, Strand, London, UK)
“Cathepsin S and fractalkine: a new modulatory pathway for neuropathic pain”
10:15-10:45 am Coffee Break
10:45-11:45 pm Session #12 Mechanisms of Chronic Central Neuropathic Pain
Claire Hulsebosch (Univ. of Texas Medical Branch, Galveston, TX, USA) Chair
“Role of Reactive Oxygen Species in Central Sensitization”
Susan Carlton (Univ. of Texas Medical Branch, Galveston, TX, USA)
“Peripheral Sensitization Contributes to Above Injury Pain Following Spinal Cord Injury”
Brian Hains (Yale University, New Haven, CT, USA)
“Mechanisms of remote microglial activation and pain signaling in central pain”
Eric Crown (Merck Research Laboratories, West Point, PA, USA)
“Intracellular Signaling Mechanisms in Central Sensitization”
Wednesday April 30th, 2008
8:00-9:00 am Session #13 Controlling the gain in the pain: receptors that modulate visceral afferent function
Gerald F. Gebhart (Univ. of Pittsburgh, Pittsburgh, PA, USA) co-Chair
“P2X3 modulation of bladder and colon afferents”
Brian M. Davis (Univ. of Pittsburgh, Pittsburgh, PA, USA) co-Chair
“TRPV1 segregation in functionally identified bladder and colon afferents”
Nathalie Vergnolle (University of Calgary, Alberta, Canada)
“TRPV4: a major role in colon hypersensitivity”
Marian Kollarik (Johns Hopkins School of Medicine, Baltimore, MD)
“Acid-mediated modulation of vagal afferent nerves”
9:00-10:00 am Session #14 Development, plasticity and modulation of visceral afferents
Brian M. Davis (Univ. of Pittsburgh, Pittsburgh, PA, USA) co-Chair
Gerald F. Gebhart (Univ. of Pittsburgh, Pittsburgh, PA, USA) co-Chair
Julie Christianson (Univ. of Pittsburgh, Pittsburgh, PA, USA)
“Effect of neonatal insult on colonic afferent function”
Alan Randich (Univ. of Alabama, Birmingham, AL, USA)
“Influence of early life experience on adult bladder inflammation and pain”
Brad Undem (Johns Hopkins School of Medicine, Baltimore, MD)
“Heterogenity of vagal afferents based on embryological origin, P2X expression and function”
Karin W. High (University of Kentucky, Lexington, Kentucky, USA)
“Gene Therapy for Pancreatitis Pain"
10:005-10:30 am Coffee Break
10:30-11:30 am Session #15 Forebrain Pain Mechanisms
Volker Neugebauer (Univ. of Texas Medical Branch, Galveston, TX, USA) Chair
"Amygdala-driven prefrontal cortical inhibition impairs cognitive function in pain"
Vasco Galhardo (Univ. of Porto, Porto, Portugal)
"Differential neurochemical changes in the amygdala and prefrontal cortex in pain"
Sabatino Maione (University of Naples, Naples, Italy)
"Morpho-functional and biomolecular changes in the pyriform and prefrontal cortex in neuropathic pain"
Sean Mackey (Stanford School of Medicine, Palo Alto, CA)
"Prefrontal cortical connectivity changes in neuropathic pain"
11:30-12:30 pm Session #16 Descending Control
Mary Heinricher (Oregon Health & Science Univ., Portland, OR, USA) Chair
“Neural basis for stress-induced hyperalgesia”
Bridget Lumb (Univ. of Bristol, UK)
“Differential descending control of A- vs C-nociceptor evoked spinal nociception”
Isaura Tavares (Univ. of Oporto, Porto, Portugal)
“Changes in descending modulation from the caudal medulla during chronic pain”
George Wilcox (Univ. of Minnesota, Minneapolis, MN, USA)
“Co-localized adrenergic and opioid receptors synergistically inhibit neuropeptide release from primary afferent terminals”
Thursday May 1st, 2008
8:00-9:15 pm Session #17 Nucleotides and Cutaneous Mechanisms of Nociception
Gregory Dussor (Univ. of Arizona, Tucson, AZ, USA) co-Chair
Derek Molliver (Univ. of Pittsburgh, Pittsburgh, PA, USA) co-Chair
“Do nucleotides set the gain on pain?”
Rick Koerber (Univ of Pittsburgh, Pittsburgh, PA, USA)
“P2Y1 and Heat Transduction in Cutaneous Polymodal Nociceptors”
Gregory Dussor (Univ of Arizona, Tucson, AZ, USA)
"MrgD+ cutaneous afferents exhibit temperature-dependent responses to ATP"
Frank Rice (Albany Medical College, Albany, NY, USA)
“Voltage-gated sodium channels on keratinocytes mediate ATP release and are upregulated under chronic pain conditions in humans and monkeys”
Anne Louise Oaklander (Harvard Medical School, Boston, MA USA)
“Non-neuronal cells in the periphery contribute to chronic pain after minor nerve injuries”
9:15-10:15 am Session #18 Metabotropic receptors for Glutamate, GABA and pain
Jean-Philippe Pin (Inst. of Functional Genomics, Montpellier, France) Co-chair
Cyril Goudet (Inst. of Functional Genomics, Montpellier, France) Co-chair
Valerio Magnaghi (Univ. of Milan, Milan, Italy)
“Nociceptive phenotypes in GABAB receptor-deficient mice”
Marc Landry (Neurosci. Inst. Univ. Bordeaux 2, Bordeaux, France)
“Impairment of GABAB inhibition in the spinal dorsal horn”
Robert W. Gereau (Washington Univ. Pain Center, St Louis, U.S.A.)
“mGlu5 activation in central sensitization”
Cyril Goudet (Inst. of Functional Genomics, Montpellier, France) Co-chair
“Developing new agonists of group-III mGluRs as potential antihyperalgesic drugs”
10:15-10:45 am Coffee Break
10:45-11:15 am Session #19 Role of Microglia in Chronic Pain Conditions
Michael H. Ossipov (Univ. of Arizona, Tucson, AZ, USA) Chair
Michael Salter (Univ. of Toronto, Toronto, Canada)
“BDNF from spinal microglia in pain hypersensitivity after peripheral nerve injury”
Kirk Johnson (Avigen Inc., Alameda CA, USA)
"AV411 - a glial attenuating drug candidate for neuropathic pain and opioid dependence"
11:15-12:45pm Session #20 Chloride Regulation in the Pain Pathway
Ted Price (Univ. of Arizona, Tucson, AZ, USA) Chair
Fernando Cervero (McGill University, Montreal, Quebec, Canada)
"Chloride co-transporters, presynaptic inhibition and touch-evoked pain: a mechanistic link?"
Ted Price (Univ. of Arizona, Tucson, AZ, USA)
"A specific role for nociceptor-expressed NKCC1 in noxious heat sensation"
Yves de Koninck (Univ. Laval, Quebec City, Quebec, Canada)
"Chloride dynamics vs neuronal excitability"
Steve Prescott (Salk Institute, La Jolla, CA, USA)
”Deciphering disinhibition through computational simulations”
Donna Hammond (Univ. of Iowa, Iowa City, IA, USA)
"Bimodal effects of an NKCC1 antagonist in models of primary and secondary allodynia"
Michael Gold (Univ. of Pittsburgh, Pittsburgh, PA, USA)
“Inflammation-induced changes in GABA-A receptor signaling in sensory neurons”
Friday May 2nd, 2008
8:00-8:45 am Session #21 Mechanisms of Analgesic Tolerance to Opioids and Cannabinoids
Rohini Kuner (Univ. of Heidelberg, Germany) Chair “Protein-protein interactions mediating analgesic tolerance to cannabinoids”
Ken Mackie (Indiana Univ., Bloomington, IN, USA)
“Desensitization mechanisms for CB1 receptor signalling”
Zhang Xu (Chinese Academy of Sciences)
“Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance”
8:45-9:45 am Session # 22 TRP Channels and Pain
Cheryl Stucky (Med College Wisconsin, Milwaukee, WI, USA) Chair
David McKemy (Univ. of Southern California, Los Angeles, CA, USA)
“Diversity in the neural circuitry of cold sensing revealed by labeling of TRPM8 neurons”
Sacha Malin (Univ. of Pittsburgh, Pittsburgh, PA, USA)
“Growth factor modulation of TRP channels in identified cutaneous, muscle and visceral afferents”
Gina Story (Washington Univ., Saint Louis, MO, USA)
“Endogenous TRPA1 activators”
Cheryl Stucky (Med College Wisconsin, Milwaukee, WI, USA)
“Role of TRPA1 in cutaneous mechanotransduction”
9:45-10:15 am Coffee Break
10:15-11:15 am Session #23 Predicting therapeutic efficacy - experimental pain in human subjects
Tony Priestley (Schering-Plough Research Institute, Kenilworth, NJ, USA) Chair
"Why we need a more efficient strategy for developing next-generation pain medications"
Michael Rowbotham (Univ. of California San Francisco, CA, USA)
"Proof-of-concept studies in patients: can the limitations of sample size, patient selection, and placebo response be overcome?"
Boris Chizh (GlaxoSmithKline, Cambridge, UK)
“Rational use of human experimental pain models in early clinical development”
Klaus Schaffler (HPR Pharmacodynamics, Munich, Germany)
"Proof of efficacy and dose-dependency of NSAID and opiate analgesics in Laser evoked potential paradigm - using capsaicin and UV skin model"
11:15-12:30 pm Session #24 Modulation of TRPA1 and TRPV1 as a Peripheral Pain Mechanism
Kenneth Hargreaves (Univ. of Texas HSC, San Antonio, TX, USA) Chair
Nathan Jeske (Univ. of Texas HSC, San Antonio, TX, USA)
"Role of AKAP in TRPV1 Sensitization"
Adrienne Dubin (Scripps Res. Inst., La Jolla, CA, USA) "Mechanisms of TRPA1 activation and modulation"
Sven E. Jordt (Yale Univ. School of Medicine, New Haven, CT, USA)
"TRPA1 in Environmental Chemosensation"
Ken Hargreaves (Univ. of Texas HSC, San Antonio, TX, USA)
"Cannabinoid regulation of TRPA1-TRPV1" Stuart Bevan (Wolfson Centre for Age-Related Diseases, London, UK)
"Naturally-occuring agonists of TRPA1"
END OF SESSIONS
Friday Evening - Farewell Beach Barbecue at the Marriott |
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